Research & Educational Use Only. This protocol guide is for informational purposes only and does not constitute medical advice. Always consult a qualified healthcare professional before beginning any research protocol.
Long-Acting Amylin Analog
Weekly Protocol Guide
Cagrilintide Protocol Guide
Cagrilintide is a long-acting acylated amylin analog studied for weight management. It works by activating amylin receptors to reduce appetite, slow gastric emptying, and promote satiety. Often studied in combination with semaglutide (CagriSema).
Protocol Overview
- Compound
- Cagrilintide (Weight Loss Research Peptide)
- Category
- Long-Acting Amylin Analog
- Vial Size
- 5mg (5,000mcg)
- Reconstitution
- 2mL bacteriostatic water (2.5mg/mL)
- Route
- Subcutaneous injection
- Frequency
- Once weekly
Reconstitution Instructions
Using 2mL of bacteriostatic water results in a concentration of 2.5mg/mL. Start at lowest dose and titrate. Always use sterile techniques.
Materials Needed
- 5mg Cagrilintide 5mg vial (lyophilized powder)
- 2mL bacteriostatic water (sterile, preserved with 0.9% benzyl alcohol)
- Sterile syringe and needle (18-22 gauge for drawing)
- Alcohol swabs
- Clean workspace
Step-by-Step Process
- Preparation: Allow the Cagrilintide 5mg vial and bacteriostatic water to reach room temperature. Wipe the rubber stoppers of both vials with an alcohol swab.
- Draw the Water: Using a sterile syringe, draw up exactly 2mL of bacteriostatic water. Expel any air bubbles.
- Inject into Vial: Insert the needle through the rubber stopper at a slight angle, aiming toward the glass wall. Slowly inject the water down the side of the vial to avoid foaming.
- Mix Gently: Remove the needle. Gently swirl or roll the vial between your hands. Do not shake vigorously.
- Check for Clarity: The solution should be clear once fully reconstituted. Do not use if cloudy.
Weekly Dosing Schedule
| Day | Units | Dose | Timing |
|---|---|---|---|
| Monday | 10 | 0.25mg | Morning |
Weekly Total: 10 units (0.25mg) • Vial Duration: ~20 weeks at starting dose
Quick Dosing Reference
| Units (Ticks) | Dose (mcg) | Dose (mg) |
|---|---|---|
| 4 | 100 | 0.1mg |
| 10 | 250 | 0.25mg |
| 20 | 500 | 0.5mg |
| 30 | 750 | 0.75mg |
| 40 | 1000 | 1.0mg |
| 60 | 1500 | 1.5mg |
| 80 | 2000 | 2.0mg |
Administration Guidelines
- Administer subcutaneously once weekly on the same day each week
- Start at 0.25mg weekly and titrate up every 4 weeks per protocol
- Rotate injection sites between abdomen, thigh, and upper arm
- Store reconstituted peptide refrigerated at 36-46F (2-8C)
- Use reconstituted solution within 30 days
- Never freeze reconstituted peptides
- Document administration times and observations
Storage Requirements
| State | Storage Conditions |
|---|---|
| Lyophilized (powder) | Room temperature or refrigerated, protect from light |
| Reconstituted | Refrigerated 36-46F (2-8C), use within 30 days |