Research & Educational Use Only. This protocol guide is for informational purposes only and does not constitute medical advice. Always consult a qualified healthcare professional before beginning any research protocol.
GHRH Analog (Long-Acting)
Weekly Protocol Guide
CJC-1295 with DAC Protocol Guide
CJC-1295 with DAC is a long-acting growth hormone-releasing hormone (GHRH) analog. The Drug Affinity Complex (DAC) binds to albumin in the bloodstream, extending the half-life to 8+ days. This allows once-weekly dosing for sustained GH elevation.
Protocol Overview
- Compound
- CJC-1295 with DAC (Modified GRF with Drug Affinity Complex)
- Category
- GHRH Analog (Long-Acting)
- Vial Size
- 2mg (2,000mcg)
- Reconstitution
- 2mL bacteriostatic water (1mg/mL)
- Route
- Subcutaneous injection
- Frequency
- Once weekly
Reconstitution Instructions
Using 2mL of bacteriostatic water results in a concentration of 1mg/mL. Always use sterile techniques.
Materials Needed
- 2mg CJC-1295 with DAC 2mg vial (lyophilized powder)
- 2mL bacteriostatic water (sterile, preserved with 0.9% benzyl alcohol)
- Sterile syringe and needle (18-22 gauge for drawing)
- Alcohol swabs
- Clean workspace
Step-by-Step Process
- Preparation: Allow the CJC-1295 with DAC 2mg vial and bacteriostatic water to reach room temperature. Wipe the rubber stoppers of both vials with an alcohol swab.
- Draw the Water: Using a sterile syringe, draw up exactly 2mL of bacteriostatic water. Expel any air bubbles.
- Inject into Vial: Insert the needle through the rubber stopper at a slight angle, aiming toward the glass wall. Slowly inject the water down the side of the vial to avoid foaming.
- Mix Gently: Remove the needle. Gently swirl or roll the vial between your hands. Do not shake vigorously.
- Check for Clarity: The solution should be clear once fully reconstituted. Do not use if cloudy.
Weekly Dosing Schedule
CJC-1295 with DAC has an extended half-life of 8+ days due to the Drug Affinity Complex. This allows once-weekly dosing at 2mg per injection.
| Day | Units | Dose | Timing |
|---|---|---|---|
| Monday (or any set day) | 200 (full vial) | 2mg (2,000mcg) | Before bed |
Standard dose: 2mg once weekly • Vial Duration: 1 dose per 2mg vial • Inject same day each week
Quick Dosing Reference (at 1mg/mL)
| Units (Ticks) | Dose (mcg) | Dose (mg) |
|---|---|---|
| 50 | 500 | 0.5mg |
| 100 | 1,000 | 1mg |
| 150 | 1,500 | 1.5mg |
| 200 | 2,000 | 2mg |
Administration Guidelines
- Administer subcutaneously once weekly on the same day each week
- Rotate injection sites between abdomen, thigh, and upper arm
- Start at 100mcg per week and adjust based on response
- 8+ day half-life due to DAC albumin binding provides sustained GH release
- Store reconstituted peptide refrigerated at 36-46F (2-8C)
- Use reconstituted solution within 30 days
- Never freeze reconstituted peptides
- Document administration times and observations
Storage Requirements
| State | Storage Conditions |
|---|---|
| Lyophilized (powder) | Room temperature or refrigerated, protect from light |
| Reconstituted | Refrigerated 36-46F (2-8C), use within 30 days |