Research & Educational Use Only. This protocol guide is for informational purposes only and does not constitute medical advice. Always consult a qualified healthcare professional before beginning any research protocol.
GLP-1 Receptor Agonist
Weekly Protocol Guide
Dulaglutide Protocol Guide
✓ Verified dosing (fact-checked against FDA labels / published trials): Dulaglutide (Trulicity), subcutaneous, ONCE WEEKLY. Start 0.75 mg once weekly; may titrate to 1.5 mg after >=4 weeks, then in 1.5 mg increments (3 mg, 4.5 mg) every >=4 weeks; max 4.5 mg/week. Single-dose prefilled pen — fixed dose, not measured in insulin 'units'. Any time of day, with/without food; abdomen, thigh, or upper arm. This supersedes any conflicting figures shown elsewhere on this page; confirm with a licensed provider.
Dulaglutide is a long-acting GLP-1 receptor agonist fused to a modified IgG4 Fc fragment, providing an extended half-life for once-weekly dosing. It is studied for glycemic control and weight management in type 2 diabetes research.
Protocol Overview
- Compound
- Dulaglutide (Trulicity - Weekly GLP-1 for Weight and T2D Research)
- Category
- GLP-1 Receptor Agonist
- Vial Size
- 3mg (3,000mcg)
- Reconstitution
- 2mL bacteriostatic water (1.5mg/mL)
- Route
- Subcutaneous injection
- Frequency
- Once weekly
Reconstitution Instructions
Using 2mL of bacteriostatic water results in a concentration of 1.5mg/mL. Start at 0.75mg and titrate. Always use sterile techniques.
Materials Needed
- 3mg Dulaglutide 3mg vial (lyophilized powder)
- 2mL bacteriostatic water (sterile, preserved with 0.9% benzyl alcohol)
- Sterile syringe and needle (18-22 gauge for drawing)
- Alcohol swabs
- Clean workspace
Step-by-Step Process
- Preparation: Allow the Dulaglutide 3mg vial and bacteriostatic water to reach room temperature. Wipe the rubber stoppers of both vials with an alcohol swab.
- Draw the Water: Using a sterile syringe, draw up exactly 2mL of bacteriostatic water. Expel any air bubbles.
- Inject into Vial: Insert the needle through the rubber stopper at a slight angle, aiming toward the glass wall. Slowly inject the water down the side of the vial to avoid foaming.
- Mix Gently: Remove the needle. Gently swirl or roll the vial between your hands. Do not shake vigorously.
- Check for Clarity: The solution should be clear once fully reconstituted. Do not use if cloudy.
Administration Guidelines
- Administer subcutaneously once weekly on the same day each week
- Start at 0.75mg weekly for at least 4 weeks then may increase to 1.5mg weekly
- Rotate injection sites between abdomen, thigh, and upper arm
- Store reconstituted peptide refrigerated at 36-46F (2-8C)
- Use reconstituted solution within 30 days
- Never freeze reconstituted peptides
- Document administration times and observations
Storage Requirements
| State | Storage Conditions |
|---|---|
| Lyophilized (powder) | Room temperature or refrigerated, protect from light |
| Reconstituted | Refrigerated 36-46F (2-8C), use within 30 days |