Research & Educational Use Only. This protocol guide is for informational purposes only and does not constitute medical advice. Always consult a qualified healthcare professional before beginning any research protocol.
Growth Hormone / Anti-Aging StackEvidence Grade: A (Tesamorelin) / B (Ipamorelin, CJC-1295)
The Ipamorelin + CJC-1295 + Tesamorelin triple stack is the most comprehensive growth hormone secretagogue protocol available. Ipamorelin is a selective GHSR agonist that triggers pulsatile GH release without cortisol or prolactin elevation. CJC-1295 DAC extends GHRH signaling with a half-life of 6-8 days, amplifying overall GH output. Tesamorelin is an FDA-approved GHRH analog specifically targeting visceral adipose tissue. Together, these three peptides synergize at different points: CJC-1295 provides sustained GHRH baseline, ipamorelin triggers acute GH pulses, and tesamorelin adds GHRH signaling with preferential visceral fat reduction.
Protocol Overview
Compounds
Ipamorelin + CJC-1295 DAC + Tesamorelin
Category
GH Secretagogue Stack
Mechanism
Ipamorelin: GHSR agonism (pulse trigger). CJC-1295 DAC: sustained GHRH analog. Tesamorelin: GHRH analog with visceral fat targeting
This stack targets three points on the GH axis simultaneously. CJC-1295 DAC provides a sustained GHRH baseline that elevates tonic GH secretion. Ipamorelin triggers acute GH pulses via ghrelin receptor agonism, creating the pulsatile pattern essential for fat loss and tissue repair. Tesamorelin adds additional GHRH signaling with unique visceral fat targeting proven in clinical trials.
Why Three Compounds?
The triple approach creates a more physiologic GH profile than any dual combination. CJC-1295 elevates the baseline, ipamorelin creates peaks, and tesamorelin specifically addresses visceral adiposity. Clinical data on tesamorelin (Egrifta) shows it reduces visceral fat by 15-20% independently, and this effect compounds with the other two secretagogues.
Combined Dosing Protocol
Protocol
Compound 1
Compound 2
Timing
Duration
Standard
Ipa 200mcg 2x/day + CJC 2mg/wk
Tesa 2mg/day
AM/PM Ipa, weekly CJC, AM Tesa
12 weeks
Advanced
Ipa 300mcg 3x/day + CJC 2mg/wk
Tesa 2mg/day
AM/pre-workout/PM
16 weeks
Pulse
Ipa 200mcg 2x/day (5on/2off) + CJC 2mg/wk
Tesa 2mg daily
Weekdays Ipa
12 weeks
Reconstitution & Preparation
Ipamorelin + CJC-1295 Preparation
Ipamorelin: 5mg vial + 2mL BAC = 2,500mcg/mL
200mcg = 8 units | 300mcg = 12 units
CJC-1295 DAC: 2mg vial + 1mL BAC = 2,000mcg/mL
2mg dose = full vial (100 units)
Tesamorelin Preparation
Tesamorelin: 2mg vials lyophilized
Reconstitute with 2mL BAC = 1,000mcg/mL
2mg dose = full vial or use larger multi-dose vial
Refrigerate all reconstituted peptides
Stacking Schedule (AM/PM Timing)
AM Protocol
Fasted AM: Tesamorelin 2mg SubQ, abdomen
30 min later: Ipamorelin 200mcg SubQ
Wait 30-60 min before eating (fasted = peak GH)
CJC-1295 DAC: once weekly (Monday)
PM Protocol
Before bed (fasted 2+ hrs): Ipamorelin 200-300mcg SubQ
Synergizes with natural nocturnal GH pulse
Do not eat after PM injection for 30+ min
Optional pre-workout dose on training days
Expected Timeline
Week 1-2
GH pulses increase. Possible water retention. Sleep quality improves from enhanced nocturnal GH. Mild hunger increase.
