LGD-4033 (Ligandrol) — Research Literature Summary

✓ Verified dosing (fact-checked against FDA labels / published trials): No FDA-approved dose exists (investigational only). The sole human-trial dosing is from Basaria 2013 Phase 1: 0.1-1.0 mg orally once daily for 21 days, with 1.0 mg/day being the highest dose ever studied. Route (oral) and frequency (once daily, justified by ~24-36 h half-life) are correct. There is NO validated human basis for 5-10 mg, for 8-12 week… This supersedes any conflicting figures shown elsewhere on this page; confirm with a licensed provider.

Class: SARM • Page type: research-literature reference • Updated 2026-04-23

Regulatory notice — research reference only

LGD-4033 is an investigational SARM that has not been approved for human use by any regulatory authority. The U.S. FDA and DOJ have explicitly enforced against sale of SARMs for human consumption. This page summarizes published preclinical and Phase I research literature only.

Published research summary

See the canonical LGD-4033 research summary page.
LGD-4033 is an orally bioavailable nonsteroidal SARM with documented HPT-axis suppression at doses greater than or equal to 1 mg/day in 21-day trials.

Why this page does not publish a consumer “cycle” schedule

No peer-reviewed support exists for consumer 'cycle' or 'PCT' protocols beyond the 21-day and 12-week fixed-dose trials above.

Peer-reviewed citations

Basaria S, et al. J Gerontol A Biol Sci Med Sci 2013;68(1):87-95. PMID 22459616.

Consulting a healthcare provider: This page is a reference for published research. If you are considering any health decision, consult a licensed healthcare provider. Path to Peptides does not provide medical advice.

⚠ Before any use: human safety data is limited or absent for many of these compounds. Consult a licensed healthcare provider first — especially if you are pregnant or nursing, have a medical condition, or take other medications.

How do you take LGD-4033 (Ligandrol)?▼

What are the storage requirements for LGD-4033 (Ligandrol)?▼

Capsules (sealed): Room temperature, cool dry place, protect from light. Capsules (opened): Keep tightly sealed, away from moisture and heat.

Frequently Asked Questions

What is the standard LGD-4033 (Ligandrol) dosing protocol?▼

See the fact-checked Verified Dosing shown at the top of this page (verified against the FDA label / published trials); always confirm with a licensed provider.

How do you take LGD-4033 (Ligandrol)?▼

LGD-4033 is taken orally as a capsule or liquid. No reconstitution or injection is needed. Take with or without food.

What are the storage requirements for LGD-4033 (Ligandrol)?▼

Capsules (sealed): Room temperature, cool dry place, protect from light. Capsules (opened): Keep tightly sealed, away from moisture and heat.