MK-677 (Ibutamoren) Protocol Guide
MK-677 (Ibutamoren) is an oral, non-peptide GH secretagogue that mimics ghrelin signaling to stimulate growth hormone release. It has a 24-hour half-life allowing once-daily dosing. Standard dosing range is 10-25mg/day. It increases GH and IGF-1 levels without affecting cortisol.
Protocol Overview
- Compound
- MK-677 (Ibutamoren) (Ibutamoren Mesylate)
- Category
- GH Secretagogue (Oral, Non-Peptide)
- Form
- Capsules (10mg, 15mg, or 25mg)
- Route
- Oral (capsule or liquid)
- Frequency
- 7 days/week
Administration
Take orally with water. No reconstitution or injection required.
- Take with or without food (unless otherwise noted)
- Store at room temperature in a cool, dry place
- Follow the dosing schedule consistently
Weekly Dosing Reference · research convention, not a validated dose
| Day | Units | Dose | Timing |
|---|---|---|---|
| Monday | 1 capsule | 10-25mg | Morning w/ food |
| Tuesday | 1 capsule | 10-25mg | Morning w/ food |
| Wednesday | 1 capsule | 10-25mg | Morning w/ food |
| Thursday | 1 capsule | 10-25mg | Morning w/ food |
| Friday | 1 capsule | 10-25mg | Morning w/ food |
| Saturday | 1 capsule | 10-25mg | Morning w/ food |
| Sunday | 1 capsule | 10-25mg | Morning w/ food |
Weekly Total: 7 capsules (175mg at 25mg/day) • Cycle Duration: 8-16 weeks (can run longer) • No PCT needed
Quick Dosing Reference · research convention, not a validated dose
| Amount | Dose | Notes |
|---|---|---|
| 1 capsule (10mg) | 10mg/day | Conservative starting dose |
| 1 capsule (15mg) | 15mg/day | Moderate dose |
| 1 capsule (25mg) | 25mg/day | Standard research dose |
Administration Guidelines
- Take orally once daily in the morning with food
- Start at 10mg/day and titrate up to 25mg/day over 2-4 weeks
- Do not crush or split capsules
- Store at room temperature in a cool dry place
- 24-hour half-life allows consistent once-daily dosing
- Monitor for water retention and increased appetite
- Document administration times and observations
Storage Requirements
| State | Storage Conditions |
|---|---|
| Sealed container | Room temperature, cool dry place, protect from moisture |
| Opened container | Room temperature, keep sealed, use within 90 days |
Related Tools & Resources
Frequently Asked Questions
There is no validated human dose for this compound; the following is a commonly cited research convention, not a validated protocol. The standard MK-677 (Ibutamoren) research protocol uses 10-25mg taken orally once daily with food. Cycle Duration: 8-16 weeks (can run longer). No PCT needed.
MK-677 is an oral capsule and does not require reconstitution. Take by mouth with food. No injection or bacteriostatic water needed.
Sealed container: Room temperature, cool dry place, protect from moisture. Opened container: Room temperature, keep sealed, use within 90 days.