Research & Educational Use Only. This protocol guide is for informational purposes only and does not constitute medical advice. Always consult a qualified healthcare professional before beginning any research protocol.
Cognitive / Nootropic StackEvidence Grade: B (Both - Approved in Russia)
Semax + Selank Stack Protocol Guide
The Semax + Selank stack is the premier cognitive peptide combination, pairing a BDNF-boosting nootropic with an anxiolytic immune-modulating peptide. Semax is a synthetic ACTH(4-10) analog that upregulates BDNF, enhances NGF, and improves dopaminergic and serotonergic transmission for focus, memory, and cognitive performance. Selank is a tuftsin analog that provides anxiolytic effects comparable to benzodiazepines without sedation or dependence, while modulating GABA and enkephalin systems. Together, Semax sharpens cognition while Selank removes anxiety, creating a calm yet focused cognitive state.
Semax is a heptapeptide analog of ACTH(4-10) that dramatically upregulates BDNF and NGF expression in the brain. It enhances dopaminergic and serotonergic neurotransmission, improves attention, working memory, and verbal fluency. Unlike stimulants, it promotes genuine neuroplasticity rather than just temporary arousal. Effects are both acute (within hours) and cumulative (building over weeks).
Selank Synergy
Selank is a tuftsin analog that provides potent anxiolytic effects by stabilizing enkephalins (natural opioid peptides) and modulating GABA-A receptor sensitivity. Unlike benzodiazepines, it produces no sedation, cognitive impairment, or dependence. By removing anxiety and mental noise, Selank allows the cognitive enhancement from Semax to manifest fully, creating the ideal focused-yet-calm mental state.
Combined Dosing Protocol
Protocol
Compound 1
Compound 2
Timing
Duration
Standard
Semax 0.1% 2 drops/nostril 2x/day
Selank 0.15% 2 drops/nostril 2x/day
AM + midday
4-8 weeks
Enhanced
Semax N-Acetyl 0.1% 2 drops 3x/day
Selank N-Acetyl 0.15% 2 drops 3x/day
AM/midday/PM
8-12 weeks
SubQ
Semax 200mcg SubQ AM
Selank 250mcg SubQ AM
AM together
6-8 weeks
Reconstitution & Preparation
Intranasal Preparation
Semax 0.1% nasal spray: ready to use
Selank 0.15% nasal spray: ready to use
N-Acetyl versions have enhanced bioavailability
Store refrigerated, use within 30 days
SubQ Preparation (Alternative)
Semax vial: reconstitute per label
Selank vial: reconstitute per label
200-250mcg doses subcutaneously
Intranasal preferred for cognitive effects
Stacking Schedule (AM/PM Timing)
AM Protocol
Morning: Semax 0.1% 2 drops per nostril
Morning: Selank 0.15% 2 drops per nostril
Wait 5 min between compounds for absorption
Effects onset within 15-30 minutes
Midday/PM Protocol
Midday (12-2 PM): Repeat both compounds
Optional PM: Selank only for evening anxiety
Avoid Semax after 4 PM if sensitive to stimulation
Effects are cumulative over days/weeks
Expected Timeline
Day 1-3
Semax effects noticeable within hours: improved focus, verbal fluency, mental clarity. Selank provides subtle calm and reduced anxiety.
