Free Functional Assessment
AI-powered root cause analysis & care plan
Start Free
Preferred vendor Β· Learn more
The Semax + Selank stack is the premier cognitive peptide combination, pairing a BDNF-boosting nootropic with an anxiolytic immune-modulating peptide. Semax is a synthetic ACTH(4-10) analog that upregulates BDNF, enhances NGF, and improves dopaminergic and serotonergic transmission for focus, memory, and cognitive performance. Selank is a tuftsin analog that provides anxiolytic effects comparable to benzodiazepines without sedation or dependence, while modulating GABA and enkephalin systems. Together, Semax sharpens cognition while Selank removes anxiety, creating a calm yet focused cognitive state.
Semax is a heptapeptide analog of ACTH(4-10) that dramatically upregulates BDNF and NGF expression in the brain. It enhances dopaminergic and serotonergic neurotransmission, improves attention, working memory, and verbal fluency. Unlike stimulants, it promotes genuine neuroplasticity rather than just temporary arousal. Effects are both acute (within hours) and cumulative (building over weeks).
Selank is a tuftsin analog that provides potent anxiolytic effects by stabilizing enkephalins (natural opioid peptides) and modulating GABA-A receptor sensitivity. Unlike benzodiazepines, it produces no sedation, cognitive impairment, or dependence. By removing anxiety and mental noise, Selank allows the cognitive enhancement from Semax to manifest fully, creating the ideal focused-yet-calm mental state.
| Protocol | Compound 1 | Compound 2 | Timing | Duration |
|---|---|---|---|---|
| Standard | Semax 0.1% 2 drops/nostril 2x/day | Selank 0.15% 2 drops/nostril 2x/day | AM + midday | 4-8 weeks |
| Enhanced | Semax N-Acetyl 0.1% 2 drops 3x/day | Selank N-Acetyl 0.15% 2 drops 3x/day | AM/midday/PM | 8-12 weeks |
| SubQ | Semax 200mcg SubQ AM | Selank 250mcg SubQ AM | AM together | 6-8 weeks |
Both compounds are extremely well-tolerated with decades of clinical use in Russia.
| Panel | Markers | Timing |
|---|---|---|
| Neuro Panel | BDNF (serum), cortisol (AM) | Baseline, Week 4 |
| Basic | CBC, CMP | Baseline, Week 8 |
| Thyroid | TSH | Baseline, Week 8 |
BDNF levels may increase 30-50% with Semax. AM cortisol tracks HPA axis function. Routine blood work is sufficient for most.
No. Neither causes dependence or withdrawal. Selank provides anxiolytic effects through enkephalin stabilization rather than direct GABA agonism, avoiding tolerance and dependence issues of benzodiazepines.
Intranasal is the standard and preferred route, providing rapid brain penetration via the olfactory pathway. SubQ is an alternative with higher systemic bioavailability but slower brain uptake. Most clinical research uses intranasal.
Semax enhances performance by upregulating BDNF/NGF and improving dopaminergic transmission. Selank removes anxiety by modulating GABA and enkephalin systems. Together they create a focused yet relaxed state ideal for complex work, learning, and creative thinking.
No. Neither causes dependence or withdrawal. Selank provides anxiolytic effects through enkephalin stabilization rather than direct GABA agonism, avoiding tolerance and dependence issues of benzodiazepines.
Intranasal is the standard and preferred route, providing rapid brain penetration via the olfactory pathway. SubQ is an alternative with higher systemic bioavailability but slower brain uptake. Most clinical research uses intranasal.
Semax enhances performance by upregulating BDNF/NGF and improving dopaminergic transmission. Selank removes anxiety by modulating GABA and enkephalin systems. Together they create a focused yet relaxed state ideal for complex work, learning, and creative thinking.
No. Neither causes dependence or withdrawal. Selank provides anxiolytic effects through enkephalin stabilization rather than direct GABA agonism, avoiding tolerance and dependence issues of benzodiazepines.
Intranasal is the standard and preferred route, providing rapid brain penetration via the olfactory pathway. SubQ is an alternative with higher systemic bioavailability but slower brain uptake. Most clinical research uses intranasal.