Research & Educational Use Only. This protocol guide is for informational purposes only and does not constitute medical advice. Always consult a qualified healthcare professional before beginning any research protocol.
Dual GLP-1/Glucagon Receptor Agonist
Weekly Protocol Guide
Survodutide Protocol Guide
✓ Verified dosing (fact-checked against FDA labels / published trials): Once-weekly subcutaneous injection. Initiate at 0.3 mg once weekly and titrate upward over ~14-16 weeks to a maintenance dose of 3.6 mg or 6.0 mg once weekly (Phase 3 obesity); MASH trials used 2.4/4.8/6.0 mg once weekly. Investigational only — not FDA-approved; no label-defined dose exists. This supersedes any conflicting figures shown elsewhere on this page; confirm with a licensed provider.
Survodutide is a dual GLP-1 and glucagon receptor agonist studied for obesity and metabolic dysfunction-associated steatohepatitis (MASH). The dual mechanism targets appetite suppression via GLP-1 while glucagon receptor activation increases energy expenditure and hepatic lipid oxidation.
Protocol Overview
- Compound
- Survodutide (Research Peptide for Obesity and MASH)
- Category
- Dual GLP-1/Glucagon Receptor Agonist
- Vial Size
- 10mg (10,000mcg)
- Reconstitution
- 2mL bacteriostatic water (5mg/mL)
- Route
- Subcutaneous injection
- Frequency
- Once weekly
Reconstitution Instructions
Using 2mL of bacteriostatic water results in a concentration of 5mg/mL. Start low and titrate gradually. Always use sterile techniques.
Materials Needed
- 10mg Survodutide 10mg vial (lyophilized powder)
- 2mL bacteriostatic water (sterile, preserved with 0.9% benzyl alcohol)
- Sterile syringe and needle (18-22 gauge for drawing)
- Alcohol swabs
- Clean workspace
Step-by-Step Process
- Preparation: Allow the Survodutide 10mg vial and bacteriostatic water to reach room temperature. Wipe the rubber stoppers of both vials with an alcohol swab.
- Draw the Water: Using a sterile syringe, draw up exactly 2mL of bacteriostatic water. Expel any air bubbles.
- Inject into Vial: Insert the needle through the rubber stopper at a slight angle, aiming toward the glass wall. Slowly inject the water down the side of the vial to avoid foaming.
- Mix Gently: Remove the needle. Gently swirl or roll the vial between your hands. Do not shake vigorously.
- Check for Clarity: The solution should be clear once fully reconstituted. Do not use if cloudy.
Administration Guidelines
- Administer subcutaneously once weekly on the same day each week
- Start at 0.25mg weekly and titrate up every 4 weeks
- Rotate injection sites between abdomen, thigh, and upper arm
- Monitor for GI side effects during titration
- Store reconstituted peptide refrigerated at 36-46F (2-8C)
- Use reconstituted solution within 30 days
- Never freeze reconstituted peptides
- Document administration times and observations
Storage Requirements
| State | Storage Conditions |
|---|---|
| Lyophilized (powder) | Room temperature or refrigerated, protect from light |
| Reconstituted | Refrigerated 36-46F (2-8C), use within 30 days |