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The MK-677 + Sermorelin stack combines an oral GH secretagogue (MK-677/Ibutamoren) with an injectable GHRH analog (Sermorelin) for comprehensive GH optimization. MK-677 is a non-peptide ghrelin receptor agonist that sustains elevated GH levels over 24 hours, increases appetite, and improves sleep. Sermorelin is a GHRH(1-29) analog that stimulates natural pulsatile GH release. Together, MK-677 provides a sustained GH baseline while sermorelin amplifies natural GH pulses, creating a more physiologic GH profile than either alone.
MK-677 (Ibutamoren) is a non-peptide oral ghrelin receptor agonist with a 24-hour half-life that provides sustained GH and IGF-1 elevation. It improves deep sleep architecture (stage 3/4 NREM), increases appetite through ghrelin mimicry, and maintains IGF-1 levels comparable to young adults. Its oral convenience makes it highly practical for long-term protocols.
Sermorelin adds natural pulsatile GHRH signaling that MK-677 alone does not provide. While MK-677 creates a relatively flat GH elevation via ghrelin, sermorelin triggers distinct GH pulses from the pituitary. This pulsatile pattern is more physiologic and may be more effective for fat loss and tissue repair than flat elevation.
| Protocol | Compound 1 | Compound 2 | Timing | Duration |
|---|---|---|---|---|
| Standard | MK-677 12.5mg oral at bedtime | Sermorelin 200mcg SubQ at bedtime | Both PM | 12 weeks |
| Enhanced | MK-677 25mg oral at bedtime | Sermorelin 300mcg SubQ at bedtime | Both PM | 12-16 weeks |
| Maintenance | MK-677 12.5mg oral EOD | Sermorelin 200mcg 3x/week | PM | 8 weeks |
| Panel | Markers | Timing |
|---|---|---|
| GH/IGF-1 | IGF-1, GH (fasted) | Baseline, Week 6, Week 12 |
| Metabolic | Fasting glucose, fasting insulin, HbA1c | Baseline, Week 8, Week 16 |
| Basic | CBC, CMP | Baseline, Week 8 |
| Lipid | Cholesterol panel | Baseline, Week 12 |
Fasting glucose monitoring is critical with MK-677. Some subjects see 5-15 mg/dL increases. Discontinue if HbA1c rises above 5.7%.
Both at bedtime. Sermorelin SubQ 30-60 min before sleep fasted, MK-677 oral at bedtime. This synergizes with the natural nocturnal GH surge and maximizes deep sleep enhancement.
MK-677 can modestly impair insulin sensitivity, particularly at 25mg. Monitor fasting glucose and HbA1c regularly. If glucose rises, reduce to 12.5mg or switch to every-other-day dosing.
MK-677 alone provides sustained but flat GH elevation. Adding sermorelin introduces pulsatile GHRH signaling that creates natural GH peaks and troughs, which is more physiologic and may be more effective for fat loss and tissue repair.
Both at bedtime. Sermorelin SubQ 30-60 min before sleep fasted, MK-677 oral at bedtime. This synergizes with the natural nocturnal GH surge and maximizes deep sleep enhancement.
MK-677 can modestly impair insulin sensitivity, particularly at 25mg. Monitor fasting glucose and HbA1c regularly. If glucose rises, reduce to 12.5mg or switch to every-other-day dosing.
MK-677 alone provides sustained but flat GH elevation. Adding sermorelin introduces pulsatile GHRH signaling that creates natural GH peaks and troughs, which is more physiologic and may be more effective for fat loss and tissue repair.
Both at bedtime. Sermorelin SubQ 30-60 min before sleep fasted, MK-677 oral at bedtime. This synergizes with the natural nocturnal GH surge and maximizes deep sleep enhancement.
MK-677 can modestly impair insulin sensitivity, particularly at 25mg. Monitor fasting glucose and HbA1c regularly. If glucose rises, reduce to 12.5mg or switch to every-other-day dosing.